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Home Publications A case of childhood acute myeloid leukemia AML (M5) with a neocentricchromosome neo(1)(qter–>q23 approximately 24::q23 approximately24–>q43–>neo–>q43–>qter) and tetrasomy of chromosomes 8 and 21.
Cancer Genet Cytogenet, 193(2), 123–126
September, 2009

A case of childhood acute myeloid leukemia AML (M5) with a neocentricchromosome neo(1)(qter–>q23 approximately 24::q23 approximately24–>q43–>neo–>q43–>qter) and tetrasomy of chromosomes 8 and 21.
de Figueiredo, Amanda Faria, Hasmik Mkrtchyan, Thomas Liehr, Eliane Maria Soares Ventura, de Jesus Marques-Salles, Terezinha, Neide Santos, Raul Corrêa Ribeiro, Eliana Abdelhay, Maria Luiza Macedo Silva

Hyperdiploidy is rarely observed in childhood acute myeloid leukemia (AML). Described here is the case of a 2(1/2)-year-old girl with AML-M5 and 51 chromosomes characterized by double tetrasomy of chromosomes 8 and 21 and also a neocentric derivative chromosome neo(1)(qter–>q23 approximately 24::q23 approximately 24–>q43–>neo–>q43–>qter). Little is known about the prognostic significance of these chromosomal abnormalities in childhood AML. In the actual case, complete remission was achieved after chemotherapy, which continued for 7 months. No acquired neocentric chromosome 1 has been described previously, even though neocentromere formation has been reported for other chromosomes in neoplasms.

Keywords: mBAND

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