About 100 guests from 36 countries met on the XVIII. MetaSystems Distributor Meeting (DM) in November to exchange experiences and to get to know new trends and developments at MetaSystems.
MetaSystems DM2019 Largest in History
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XL IRF4 BA
Break Apart Probe
- Order Number
- D-6040-100-OG
- Package Size
- 100 µl (10 Tests)
- Chromosome
- 066
- Regulatory Status
- IVDD
IVDR Certification
MetaSystems Probes has already certified a large part of its portfolio, according to IVDR. For organizational reasons, we currently provide only the IVDD product.
Discover all IVDR-certified products
XL IRF4 BA consists of a green-labeled probe hybridizing proximal to the IRF4 gene region at 6p25 and an orange-labeled probe hybridizing distal to the IRF4 gene region at 6p25.
Probe maps are created in accordance with the intended purpose of the product. Solid colored bars do not necessarily indicate that the probe fully covers the indicated genomic region. Therefore, caution is advised when interpreting results generated through off-label use. Probe map details based on UCSC Genome Browser GRCh37/hg19. Map components not to scale. Further information is available on request.
The updated (2016) revision of the World Health Organization (WHO) classification of tumors of lymphoid neoplasms considers the large B-cell lymphoma with IRF4 rearrangement as a new provisional entity. Head and neck regions including the Waldeyer ring are particularly affected. Chromosomal translocations involving the IRF4 gene and the immunoglobulin loci IGH, IGL and IGK (IG) result in dysregulation of IRF4 expression; other translocation partners may occur. Since t(6;14)(p25;q32) is cytogenetically cryptic, FISH is a valuable tool in detecting this recurrent aberration. IG/IRF4 positive lymphomas normally lack t(14;18), which is observed in about 85% of adult patients with follicular lymphoma, and are commonly associated with young age and a good course. IRF4 rearrangements have also been identified in peripheral T-cell lymphomas (PTCL). PTCL are defined as a diverse group of aggressive lymphomas of mature-stage T-cells accounting for about 10% of non-Hodgkin lymphomas. Recent data suggests that IRF4 translocations detected by FISH have a predictive value for primary cutaneous CD30(+) anaplastic large cell lymphoma.
Clinical Applications
- Non-Hodgkin Lymphomas (NHL)
XL IRF4 BA hybridized to lymphozytes. One aberrant cell with split signal is shown, indicating a break in the IRF4 locus. Additionally, one normal interphase is shown.
Normal Cell:
Two green-orange colocalization/fusion signals (2GO).
Aberrant Cell (typical results):
One green-orange colocalization/fusion signal (1GO), one separate green (1G) and orange (1O) signal each resulting from a chromosome break in the respective locus.
- Feldman et al (2009) Leukemia 23:574-580
- Salaverria et al (2011) Blood 7:139-147
- Kiran et al (2013) Leukemia Research 37:396-400
Fact Sheet (English)Package Insert (EN)Package Insert (IT)Probes Catalog
Certificate of Analysis (CoA)
or go to CoA DatabaseSecond MetaSystems User Day in Altlussheim, Germany
Neon, the outstanding MetaSystems case and image management system, offers many tools and helpful gadgets to streamline routine workflows, for example in cytogenetics labs. The second MetaSystems User Day, addressed to MetaSystems clients from Germany, Austria, and Switzerland, provided in different workshops knowledge helping to unleash the full power of the system.
OOO MetaSystems Russia on the International Scientific Congress 'Genetics of XXI Century'
The Congress 'Genetics of XXI Century' in Moscow, Russia (May 2019) has been one of the most important events for the professional international community of geneticists. Our partner company in Russia OOO MetaSystems considered it a good occasion to present the new camera CoolCube 4 connected to a state-of-the-art Neon system to the public.
