XA AneuScore I

Aneusomy Probe

Order Number
D-5604-500-TC
Package Size
(2x 50 Tests)
Labels
   
Chromosomes
131821XY
Regulatory Status
IVDR

IVDR Certification

This probe is IVDR-certified in compliance with the Regulation (EU) 2017/746 on in vitro diagnostic medical devices (IVDR). For organizational reasons, we currently provide only the IVDD product.

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Intended Purpose

The XA 13/21 enumeration probe is a qualitative, non-automated test for the detection of copy number variations of chromosome 13 and chromosome 21 by fluorescence in situ hybridization (FISH). The XA X/Y/18 enumeration probe is a qualitative, non-automated test for the detection of copy number variations of chromosome X, chromosome Y and chromosome 18 by fluorescence in situ hybridization (FISH). The products are intended for prenatal testing of pregnancies at risk for copy number variations of chromosomes X and chromosome Y and trisomy 13, trisomy 18 and trisomy 21 on methanol/acetic-acid fixed uncultured amniocytes.

Product Description

The XA AneuScore I contains different probe mixes provided in separate test vials.

XA 13/21 (D-5602-100-OG)
The XA 13/21 enumeration probe consists of a green-labeled probe hybridizing to the RB1 gene region at 13q14.2 and an orange-labeled probe hybridizing to the DSCR4 gene region at 21q22.1-22.2.

XA X/Y/18 (D-5606-100-TC)
The XA X/Y/18 enumeration probe consists of a green-labeled probe hybridizing to the centromere of the X-chromosome, an orange-labeled probe hybridizing to the centromere of the Y-chromosome and an aqua-labeled probe hybridizing to the centromere of the chromosome 18.

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Images

XA AneuScore I

XA AneuScore I probe kit hybridized to normal lymphocytes. XA X/Y/18 (up) shows signals at the centromeric regions of the X chromosme in green, the Y chromosme in orange, and chromosme 18 in blue. The XA 13/21 (down) shows orange signals at 21q22 and green signals at 13q14.

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Expected Patterns

Expected Pattern 1

For signal patterns please refer to: XA 13/21 (D-5602-100-OG) and XA X/Y/18 (D-5606-100-TC).

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Downloads

Probes Catalog

Certificate of Analysis (CoA)

or go to CoA Database

News

MetaSystems DM2019 Largest in History

About 100 guests from 36 countries met on the XVIII. MetaSystems Distributor Meeting (DM) in November to exchange experiences and to get to know new trends and developments at MetaSystems.

MetaSystems DM2019 Largest in History

New MetaSystems Office in Latin America

MetaSystems proudly announces the opening of our first subsidiary in the Southern hemisphere. The new office is located in Buenos Aires, Argentina and bears the name MetaSystems Latinoamérica SAS (MetaSystems LatAm). The foundation has been the response to the growing demand on technical knowledge and 'know how' experienced in the last years all over the Latin American territories. MetaSystems LatAm takes care for the organization of sales, support, and customer relation activities in all countries in Latin America. It will manage distributor companies and contacts in the region, and it will facilitate communication between end-users, distributors and headquarters in Germany.

New MetaSystems Office in Latin America

MetaSystems Workshop in Dehradun, India

A “Hands-on Workshop on FISH and its application in Pathology and Clinical Medicine” was organized by MetaSystems and Department of Pathology, Himalayan Institute of Medical Sciences (HIMS) to demonstrate the applications of FISH in hematological malignancies and solid tumors.

MetaSystems Workshop in Dehradun, India